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Learn about the biological effects of psilocybin

 

Now that you have heard about the physiological effects of psilocybin, you may be wondering if it really works. Click HERE to learn about some case studies.

Hallucinogens are very experimental because so little is known about substances like psilocybin. Although us researchers don’t know exactly how psilocybin functions in the brain, we can still conclude that psilocybin seems to be a very effective drug, as can be seen from the testimonies here. For the most part psilocybin is not too effective at treating pain (Grob, Charles S., Danforth, Alicia L., Chopra, Gurpreet S., et al) . Furthermore, many patients do experience a spike of anxiety and distress when taking the drug. However, the overall, and long lasting effects of psilocybin show that patients experience a sense of being ego-free, less anxious and depressed, and patients learn to accept their current health condition. The government is slowly allowing a small number of universities and other research facilities to conduct research on psilocybin and its effects, which may lead to more knowledge about the drug and more accessibility to psilocybin for those who need it (Pollan).

        What precisely goes on in the brain when someone takes a hallucinogen like psilocybin or LSD is not fully understood. At about 10 mg psilocybin can have psychological effects; stronger effects occur with higher dosages (Grob, Charles S., Danforth, Alicia L., Chopra, Gurpreet S., et al).  Some research shows that hallucinogens distort communication between neurotransmitters in the nervous system (National Institute on Drug Abuse). The affected neurotransmitters are commonly associated with regulating perception, hunger, sleep, mood, muscle control, and much more (National Institute on Drug Abuse). Psilocybin in particluar blocks serotonin receptors for about 4-6 hours (Grob, Charles S., Danforth, Alicia L., Chopra, Gurpreet S., et al). Serotonin is a nuerotransmitter that effects ones mood; a lack of serotonin in the brain can cause depresion (Serotonin: What is serotonin and what does it do?).

The Biology Behind Psilocybin

© 2015 SocGen 108: Francesca Essilfie, Monica Morucci, Pardes Seleh, and Sam Wang. This website was created by undergrad students in UCLA's Human Biology and Society Major, as part of a capstone course requirement.  Questions or comments can be directed to the Institute for Society and Genetics at UCLA (socgen@socgen.ucla.eduProudly created with Wix.com

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